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Motor behavior improvement in ischemic gerbils by cholinergic receptor activation and treadmill training

By
Lucas Hipolito do Espírito Santo ,
Lucas Hipolito do Espírito Santo

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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Kelly Zhang ,
Kelly Zhang

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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Takae Tamy Kitabatake ,
Takae Tamy Kitabatake

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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Manoela Gallon Pitta ,
Manoela Gallon Pitta

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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Gustavo Henrique de Mello Rosa ,
Gustavo Henrique de Mello Rosa

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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Elaine Caldeira de Oliveira Guirro ,
Elaine Caldeira de Oliveira Guirro

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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João Eduardo de Araujo ,
João Eduardo de Araujo

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences, Ribeirão Preto, Brazil.

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Abstract

Introduction: Treadmill exercise training is one of the most investigated non-pharmacological treatment options for experimental brain ischemia. However, the cholinergic system is essential for improving motor behavior responses.
Objective: To analyze the effects of a nicotinic acetylcholine receptor (nAChR) agonist (1, 2, and 4 mg/kg) on the motor behavior of ischemic gerbils subjected to forced treadmill training.
Methods: In this experimental study, 72 gerbils, weighing 65–80 g, were divided into eight groups: Sal, Ni1, Ni2, Ni4, I, INi1, INi2, and INi4. Behavioral assessment was initiated 24 hours after the last motor stimulation on the treadmill. Rotarod test (RR) was employed to analyze animal behavior. The data were analyzed using one-way analysis of variance (ANOVA), and the Newman-Keuls post hoc test evidenced differences detected between groups.
Results: Data regarding the RR test revealed decreased time spent on the RR apparatus for the Ni1, Ni4, and I groups compared to the Sal and Ni2 groups. However, the INi1 and INi2 groups showed increased time spent compared with the ischemia and INi4 groups (F7,64=4.63; p<0.05).
Conclusions: The present study indicates that treadmill training with a concomitant 1 and 2 mg/kg of nAChR agonist effectively improves the behavior of ischemic gerbils.

How to Cite

1.
do Espírito Santo LH, Zhang K, Kitabatake TT, Gallon Pitta M, de Mello Rosa GH, de Oliveira Guirro EC, de Araujo JE. Motor behavior improvement in ischemic gerbils by cholinergic receptor activation and treadmill training . Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria [Internet]. 2024 Apr. 1 [cited 2024 May 30];4:69. Available from: https://ri.saludcyt.ar/index.php/ri/article/view/69

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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