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Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils

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Manoela Gallon Pitta ,
Manoela Gallon Pitta

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences. Ribeirão Preto, Brazil

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Kelly Zhang ,
Kelly Zhang

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences. Ribeirão Preto, Brazil

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Gustavo Henrique de Mello Rosa ,
Gustavo Henrique de Mello Rosa

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences. Ribeirão Preto, Brazil

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Lucas Hipolito do Espírito Santo ,
Lucas Hipolito do Espírito Santo

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences. Ribeirão Preto, Brazil

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Elaine Caldeira de Oliveira Guirro ,
Elaine Caldeira de Oliveira Guirro

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences. Ribeirão Preto, Brazil

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João Eduardo de Araujo ,
João Eduardo de Araujo

Ribeirão Preto Medical School University of São Paulo, Department of Health Sciences. Ribeirão Preto, Brazil

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Abstract

Introduction: Ischemic stroke stands as a leading global cause of death and disability, prompting the need for animal model experiments in stroke research and the protection of motor function. Recently, magnetic fields have gained significant interest in various biological contexts, showing promise in preserving neurons and reversing behavioral and morphological changes in stroke models. This study explores the potential synergy between static magnetic field and nAChR agonist administration in safeguarding motor behavior in ischemic gerbils.
Objective: To determine whether the combined use of a static magnetic field and an agonist for nicotinic acetylcholine receptors (nAChR) can preserve motor behavior in ischemic gerbils.
Methods: In this experimental study, 72 Mongolian gerbils were randomly allocated into nine groups (n=8): S, SISM, SINSM, ISM, INP, ISP, INSM, INNP, INSP, distributed according to surgical procedure and treatment. The animals were trained and evaluated on the Rotarod (RR) to assess motor performance.
Results: The main finding was the preservation of motor behavior in the Sham Ischemia and Nicotine and Sham Magnetic Stimulation (SINSM) and Ischemia and Nicotine and South Pole Magnetic Field (INSP) groups, as evidenced by the results of the RR test.
Conclusions: The findings are consistent with previous literature and provide insight into the mechanism of potentiation, as results showed that adding a nAChR agonist to the magnetic field preserved motor performance in the RR test of ischemic animals.

How to Cite

1.
Gallon Pitta M, Zhang K, de Mello Rosa GH, do Espírito Santo LH, de Oliveira Guirro EC, de Araujo JE. Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils: Effects of Cholinergic Receptor Activation and Magnetic Fields. Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria [Internet]. 2024 Feb. 11 [cited 2024 May 30];4:70. Available from: https://ri.saludcyt.ar/index.php/ri/article/view/70

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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